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Taken together, GLP-1RA therapy can be viewed as a sustained remodeling of systemic energy flux and substrate prioritization

However, as we age, our NAD+ production naturally diminishes, resulting in a 40% reduction by the time we reach 40 years of age

64,65 In particular, because CKD contributes to the progression of cardiovascular disease through many pathways, the authors of a 2021 review published in Circulation stated that CKD mimics an accelerated aging of the cardiovascular system. 66 Blood Clot and Bleeding Risks Chronic kidney disease increases the risk of bleeding events as well as blood clots (thrombosis) and related health problems

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